T细胞斑点试验技术在结核性胸膜炎诊断中的临床价值

The Clinical Value of T Cell Spot Test Technology in the Diagnosis of Tuberculous Pleurisy

目的分析T细胞斑点试验技术诊断结核性胸膜炎的临床价值。方法选择初诊结核性胸膜炎患者、恶性胸腔积液患者、非结核性胸膜炎患者以及同期健康体检者,经T细胞斑点试验技术检测各组受试者外周血单个核细胞中对结核分枝杆菌早期分泌靶向抗原6和培养液蛋白10致敏的T细胞。结果结核性胸膜炎组T细胞斑点试验技术检测阳性率较其他各组均有所升高(P<0.05);T细胞斑点试验技术对结核性胸膜炎诊断的敏感性、特异性以及准确性均较腺苷脱氨酶高(P<0.05)。结论 T细胞斑点试验技术在结核性胸膜炎辅助诊断中具有临床价值。

Objective To analyze the T cell spot test technology the clinical value of diagnosis of tuberculous pleurisy. Methods First diagnosis of tuberculous pleurisy patients, patients with malignant pleural effusion and tuberculous pleurisy patients and healthy physical examination was selected to study during this period, T Spot TB test subjects in each group,test the targeting antigens 6 early secreted from mycobacterium tuberculosis and Protein 10- sensitized T cells in culture fluid in peripheral blood mononuclear cells. Results Tuberculous pleurisy group T cells spot test technology test positive rate than other groups were significantly higher（P 0.05）; T cells spot test technique for diagnosis of tuberculous pleurisy sensitivity, specificity and accuracy were relatively high adenosine deaminase（P 0.05）. Conclusion T-cell spot test technique in assistant diagnosis of the tuberculous pleurisy has significant clinical value.