摘要
目的:探讨Th亚群以及IL-17在牙周炎发病中的作用。方法:用流式细胞术检测健康对照10例,慢性牙周炎(CP)11例,侵袭性牙周炎(AgP)8例患者外周血中辅助性T细胞亚群Th1、Th2、Th17的水平,ELISA法检测龈沟液(GCF)中IL-17的水平。结果:与正常对照组相比2组牙周炎患者外周血中Th1、Th17所占比例明显升高(P<0.01),Th2比例明显降低(P<0.01);龈沟液内IL-17浓度明显升高(P<0.01)。CP组IL-17浓度与PD和AL正相关(P=0.000),AgP组IL-17与PD正相关(P=0.007)。结论:牙周炎患者机体免疫功能降低,龈沟液中IL-17升高与牙周炎发生发展有关。
Objective:To study the correlation of Th subsets in peripheral blood(PB) and IL-17 in gingival crevicular fluid(GCF) in the patients with periodontitis.Methods:10 healthy controls,11 cases with chronic periodontitis(CP) and 8 cases with aggressive periodontitis(AgP) were included.Th1,Th2 and Thl7 in PB were measured by flowcytometry,IL-17 in GCF was examined by ELISA.Periodental indexes(PLI,PD,AL and BI) were measured.Results:In the CP group and the AgP group,Thl and Thl7 were significantly higher,Th2 was lower than those in the control group(P〈0.01)(between CP and AgP groups,P〈0.05),and IL-17 in GCF were significantly higher(P〈0.01)(between CP and AgP groups,P〉0.05).In group CP IL-17 leve in GCF was positively correlated with PD and AL(P =0.000),in group AgP with PD(P =0.007).Conclusion:Deficiency of immunologic function and increase of IL-17 in the GCF is related with the onset and development of periodontitis.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2015年第6期844-847,共4页
Journal of Practical Stomatology