纳米粒子对amyloid-β聚集的影响的研究进展

Review of the influence of nanoparticles on aggregation of amyloid-β

阐述金属复合物和纳米粒子对β-类淀粉蛋白(amyloid-β,Aβ)聚集影响的最新研究进展.指出Aβ蛋白聚集过程始于寡聚体内核的组装,最终形成具有β-片层结构的螺旋状纤维.纳米粒子对纤维形成中的每一阶段都可能产生抑制或促进作用,从而影响Aβ的纤维化聚集.认为揭示Aβ聚集的影响因素及其作用机理,将有助于控制Aβ的纤维化聚集,减少其神经毒性,以此可寻找治疗阿尔茨海默症(Alzheimer's disease,AD)的途径.

This paper reviews the influence of metal complexes and nanoparticles on the aggregation of amyloid-β （AIS）. The amyloid fibrillation starts from the assembly of the oligomer core and eventually assembls into helical fibrils with β-sheet. Nanoparticles are found to have considerable influence on the A β fibrillar aggregation. Revealing how these factors influence the mechanism of A-β aggregation will be helpful to control the fibrillar aggregation and reduce its neurotoxicity, thus might provide efficient ways for the treatment of Alzheimer＇s disease eventually.