信号放大策略在电化学生物传感器中的应用

The application of signal amplification strategies in electrochemical biosensors

近年来,快速、简单、灵敏的生物分子检测在临床诊断、食品分析、生物恐怖主义的防御和环境监测等方面变得日益重要。电化学生物传感器由于具有简单、灵敏、成本低并可广泛运用于不同领域的固有优势而受到越来越多的关注。为了实现高灵敏的生物检测,不同信号放大方法被用于传感器的构建中。该文简单介绍了电化学生物传感器的基本原理,并重点概括了广泛运用于电化学生物传感器中的信号放大策略。

Rapid, simple and sensitive determination of biomolecules has become increasingly important in clinical diagnosis, food analysis and bioterrorisrn/environmental monitoring over the past few years. Electrochemical biosensor has gained increasing interest due to its inherent advantages such as simplicity, sensitivity and low cost in cooperation with the comprehensive applications in different fields. Various signal amplification methods have been reported to achieve high sensitivity for biomolecules determination. In this article, we briefly introduce the fundamentals of the electrochemical biosensor, and emphatically summarize the popular signal amplification strategies applied in electrochemical biosensors.