摘要
目的通过采用双倍剂量口服生血宁片治疗慢性肾脏病（chronic kidney disease，CKD）3～4期肾I生贫血患者，探讨其对患者血红蛋白（hemoglobin，Hb）达标率提高以及铁代谢指标的变化情况。方法选择2014年4月至2015年10月烟台市中医院门诊及住院治疗的CKD3～4期患者60例，采用随机数字表法分为治疗组和对照组，每组30例。2组均给予低盐优质低蛋白质饮食（0．6～0．8g·kg-1·d-1），常规口服叶酸、维生素B12等综合治疗的同时，治疗组口服生血宁片，每日3次，每次4片；对照组口服生血宁片，每日3次，每次2片；治疗时间为16周。每2周检测Hb、血清铁（serumiron，SI）、血清铁蛋白（serum ferritsn，SF）及转铁蛋白饱和度（transferin saturation，TSAT）。结果2组经生血宁片治疗后第16周，Hb、SI、SF、TAST均得到改善，治疗前与治疗后差异有统计学意义（P〈0．05），且治疗组的Hb、SI、SF及TAST均较对照组改善明显（P〈0．05）。2组疗效比较，治疗组总有效率96．7％，对照组总有效率86．7％；2组总有效率比较有统计学差异（P〈0．05）。结论对于CKD3～4期患者，双倍剂量生血宁片（4片／次，每日3次）较单倍剂量能有效纠正贫血，提高铁利用效率，改善铁代谢，疗效更为明显。同时双倍剂量生血宁片临床疗效安全，2组患者不良反应发生率相当，未见明显差异。
Objective To evaluate the clinical efficacy of Shengxuening tablets （SXN） in the treatment of patients with renal anemia of CKD 3 to 4 phase, and observe the improvement of hemo- globin and the change of iron metabolism index. Methods Sixty cases of renal anemia of CKD3-4 were randomly divided into two groups： control group and treatment group, 30 cases each group. The cases of the two groups were given low salt, high quality low protein diet, and Folic acid and vitamin B12. The treatment group received SXN, 3 times a day, each time 4 pieces, and the control group given SXN, 3 times a day, each time 2 pieces for 16 weeks. Observation index included hemoglobin （Hb）, serum iron （SI）, serum ferritsn （SF） and transferin saturation （TSAT）. Results As compared with the control group, the levels of HB, SI, SF and TAST were significantly decreased after SXN treatment （P〈0. 05）. The total effective rate was 96. 7% in the treatment group and 86. 7% in the control group, and the total efficiency comparison of the two group had statistical difference （P〈0. 05）. Conclusions For patients with CKD3 to 4, double dose SXN could effectivly correct anemia, and improve iron utilization and iron metabolism. Double dose SXN was safe and had no obvious adverse reactions.
出处
《临床肾脏病杂志》
2015年第10期616-619,共4页
Journal Of Clinical Nephrology
关键词
慢性肾脏病
肾性贫血
生血宁
Chronic kidney disease
Renal anemia
Shengxuening
