炎症因子、免疫细胞和纤维蛋白原联合检测在COPD中的应用

Application of combined detection inflammatory factor, immune cells and fibrinogen in COPD

目的：探讨血清炎症因子、免疫细胞联合纤维蛋白原在COPD患者中水平变化，并探讨其与感染细菌类型的关系。方法：回顾性分析我科收治的50例COPD患者作为观察组，测定血清炎症因子IL-6、IL-8和纤维蛋白原水平，同时测定中心粒细胞和淋巴细胞水平，并计算比值（NLR）；选取同期在我院体检的健康人50例作为对照组，观察血清学指标与肺功能指标的关系，并对患者进行三年随访，观察其与预后的关系。结果：COPD患者血清IL-6、IL-8、NLR和纤维蛋白原水平明显高于正常人，其差异有统计学意义（P〈0.05）；IL-6、IL-8、NLR和纤维蛋白原水平越高，肺功能指标越差，其相关性系数为0.87，差异有统计学意义（P〈0.05）；随访三年后，血清IL-6、IL-8、NLR和纤维蛋白原水平越高，死亡率越高。结论：血清炎症因子IL-6、IL-8、NLR和纤维蛋白原联合检测可以明确诊断COPD，同时间接判断肺功能和预后，具有重要的临床意义。

Objective：To investigate the value of serum FBG combined with inflammatory cytokines and immune cells in the patients with COPD , and to explore its relationship with theinfection of bacteria types.Methods：A retrospective analysis of 50 cases of COPD treated in our hospital were as the observation group, the serum inflammatory cytokines IL-6, IL-8 and fibrinogen, and select the same period in healthy elderly physical examination in our hospitalas control group, to observe the relationship between the serum and lung function index, andwere followed for three years to observe patients. Its relationship with the prognosis.Results： The serum COPD in patients with IL-6, IL-8 and fibrinogen levels were significantly higher than that of normal people, the difference was statistically significant （P〈0.05）. IL-6, IL-8 andfibrinogen level is higher, the worse lung function indexes, the correlation coefficient was 0.87,the difference was statistically significant （P〈0.05）; after three years of follow-up, the levels of serum IL-6, IL-8 and fibrinogen level is higher, the higher death rate.Conclusions：The serum levels of inflammatory cytokines IL-6, IL-8 and fibrinogen detection can diagnose COPD, andindirect judgment of pulmonary function and prognosis has important clinical significance.