病毒灭活新鲜冰冻血浆制备前后凝血因子变化研究

The research of clotting factor change before and after the preparation of fresh frozen plasma by virus inactivation

目的：探讨新鲜冰冻血浆病毒灭活前后凝血因子之间的存在的差别，为临床选择使用不同血浆制品提供依据。方法：随机抽取30人份新鲜冰冻血浆病毒灭活前后各类凝血因子[凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）、血浆纤维蛋白原（FIB）、凝血酶时间（TT）、凝血因子Ⅷ（FⅧ）]进行对比。结果：新鲜冰冻血浆经病毒灭活后PT、FIB、TT无明显变化（P＞0.05），APTT、FⅧ活性水平则显著降低（P＜0.05）。结论：新鲜冰冻血浆尽管病毒灭活后部分凝血因子含量有所降低，但仍高于国家标准，而且在灭活掉经血传播病毒后，其临床输注安全性得以保障。建议医疗机构根据临床输血指征、两种血浆的各自优缺点，合理输注上述两种血浆，达到输注合理、安全、有效的目的。

Objective：Discussion of fresh frozen plasma before and after viral inactivation differences that exist between the clotting factor for clinical choose to use a different blood products provided basis.Methods：Random sample of 30 people Front and rear parts of all kinds of fresh frozen plasma viral inactivation of clotting factor [prothrombin time （PT）, activated partial thromboplastin time （APTT）, plasma fibrinogen （FIB）, thrombin time （TT）, coagulation factor Ⅷ （FⅧ）] were compared.Results：PT, FIB, TT had in Fresh frozen plasma viral inactivation after no significant change （P〉 0.05）, APTT, FⅧ activity levels significantly decreased （P 〈0.05）.Conclusions：While some fresh frozen plasma coagulation factor levels after viral inactivation has decreased, but still higher than the national standard, and in the blood-borne virus inactivation off, the clinical transfusion safety can be guaranteed. we recommends that medical institutions based on clinical transfusion indications, advantages and disadvantages of two plasma reasonable infusion of both plasma infusion to achieve a reasonable, safe and effective purpose.