hs-CRP和PLT动态监测新生儿败血症病情临床意义及联合检测价值探讨

The discussion on clinical significance of hs-CRP and PLT dynamic monitoring neonatal sepsis condition and combined detection value

目的：研究hs-CRP和PLT动态监测新生儿败血症病情临床意义及联合检测价值，探讨其临床适用性。方法：选择从2013年5月至2014年11月于我院新生儿科接受治疗新生儿败血症的46例患儿作为研究组，另取46例健康新生儿作为对照组，分别对两组新生儿进行hs-CRP和PLT及两者联合检测，观察两组新生儿治疗前后的hs-CRP、PLT含量以及单一检测与联合检测的特异度、灵敏性、阳性预期值和阴性预期值等。结果：治疗前，研究组患儿的hs-CRP含量明显高于对照组，PLT含量明显低于对照组，且差异均具有统计学意义（P＜0.05）；治疗后，两组差异均无统计学意义（P＞0.05）；同时研究组患儿hs-CRP较PLT诊断价值高，而联合检测又明显高于单一检测，差异具有统计学意义（P＜0.05）。结论：hs-CRP和PLT检测对新生儿败血症的诊断具有一定的价值，两项指标联合检测的诊断价值更高，适合临床推广应用。

Objective：To study the clinical significance of hs-CRP and PLT dynamic monitoring and value of combined detection on neonatal sepsis, and to explore its clinical applicability.Methods：46 cases of neonatal sepsis from May 2013 to November 2014 in our hospital were Served as a research group , Another 46 cases of healthy newborns were served as a control group. Observed and compared before and after treatment hs-CRP and PLT and of the two groups , specificity, sensitivity, positive detection rate of a single detector and joint detection.Results：Before treatment, hs-CRP content of the study group was significantly higher than the control group, the PLT was significantly lower than the control group, the differences were statistically significant （P〈0.05）; after treatment,the differences of hs-CRP and PLT in two groups were not statistically significance （P〉0.05）; while the diagnostic value of hs-CRP, PLT in study group was higher than the control group, and the diagnostic value of joint detection was significantly higher than the hs-CRP, PLT, the difference were statistically significant （P〈0.05）.Conclusions：hs-CRP and PLT detection has a certain value in the diagnosis of neonatal sepsis, but the diagnostic value of combined detection is higher ,and it is suitable for clinical application.