甘胆酸与总胆汁酸在妊娠期早期肝内胆汁淤积临床诊断分析

The clinical diagnosis analysis of serum cholyglycine and total bile acid detection in intrahepatic cholestasis of early pregnancy

目的：分析血清甘胆酸（CG）、总胆汁酸（TBA）测定对妊娠期肝内胆汁淤积症（ICP）的诊断价值及意义。方法：免疫比浊法测定健康组和病例组血清甘胆酸浓度,循环酶法检测正常组和异常组总胆汁酸（TBA）的浓度。结果：妊娠期肝内胆汁淤积症患者的血清甘胆酸、总胆汁酸测定结果均明显高于正常孕妇（P〈0.05）。结论：血清甘胆酸、总胆汁酸的测定对妊娠期肝内胆汁淤积症的诊断是有临床价值的,同时监测上述指标可以早期诊断ICP，并及时干预，达到母婴安全。

Objective：To study clinical diagnostic significance of serum cholyglycine（CG） and total bile acid（TBA） detection in intrahepatic cholestasis of pregnancy（ICP）.Methods：We respectively measure the concentration of CG and TBA for patients with ICP and normal control group.Results：The concentration of CG and TBA were higher in patients with ICP than those in normal group（P〈0.05）.Conclusions：The detection of CG and TBA levels have clinical diagnostic significance to ICP disease. It is better for early treatment.