血清降钙素原在细菌性脑膜炎诊断中的应用

The significance of serum procalcitonin in diagnosis of bacterial meningitis

目的：评价血清降钙素原在细菌性脑膜炎鉴别诊断中的临床意义。方法：对22例儿童细菌性脑膜炎和15例儿童病毒性脑膜炎进行血清降钙素原、C-反应蛋白检测，同时以20例正常体检人群做对照。结果：细菌性脑膜炎组血清降钙素原和C-反应蛋白明显高于病毒性脑膜炎组和对照组，差异均具有统计学差异（P＜0.05），PCT能显著区分开细菌性和病毒性脑膜炎，CRP在两组间存在浓度重叠，无法完全区分开细菌性和病毒性脑膜炎。PCT诊断细菌性脑膜炎的灵敏度和特异性为95%，99%，CRP诊断细菌性脑膜炎的灵敏度和特异性为83%，87%。结论：血清降钙素原对于细菌性脑膜炎具有优异的鉴别和诊断效果，优于C-反应蛋白。

Objective：To evaluate the clinical significance of serum procalcitonin in identification and diagnosis of bacterial meningitis.Methods：Among the 22 children bacterial meningitis and 15 children bacterial meningitis,serum procalcitonin（PCT）、C-reactive protein（CRP） concentration levels were measured. And 20 outpatients were measured as normal control.Results：The level of PCT and CRP was significantly higher in the bacterial meningitis group than the viral meningitis group and normal control, there were significant differences in the two groups（P〈 0.05） . Using the receiver operating characteristic （ ROC） curve , take serum PCT 〉6 ng/ ml as a threshold for the diagnosis of children bacterial meningitis, the sensitivity is 95% and specificity is 99%. However, take serum CRP 〉25mg/L as a threshold for the diagnosis of children bacterial meningitis, the sensitivity is 83% and specificity is 87%. Conclusions：It suggested that serum procalcitonin can be useful in identification and diagnosis of severe acute pancreatitis,better than CRP.