艾司西酞普兰联合唑吡坦治疗原发性失眠的临床疗效观察

Clinical Effect of Escitalopram Combined with Zolpidem in the Treatment of Primary Insomnia

目的:探讨艾司西酞普兰联合唑吡坦治疗原发性失眠的临床疗效。方法:84例原发性失眠患者随机分为观察组与对照组,各42例,对照组用唑吡坦治疗,观察组用艾司西酞普兰联合唑吡坦治疗,比较两组治疗效果。结果:匹兹堡睡眠质量指数量表总分比较,两组治疗前的无明显差别(P>0.05),治疗后1、4、8周,观察组皆明显低于对照组(P<0.05)。不良反应发生率,观察组占31%,对照组占28.6%,两组比较差异无显著性(P>0.05)。结论:艾司西酞普兰联合唑吡坦治疗原发性失眠能起到改善患者睡眠质量的效果,不良反应低。

Objective： To investigate the clinical efficacy of escitalopram combined with zolpidem in the treatment of primary insomnia. Methods： 84 patients with primary insomnia patients were randomly divided into observation group and control group, 42 cases in each, zolpidem therapy was used in the control group, observation group by escitalopram combined with zolpidem therapy, treatment effects were compared between the two groups. Results： There was no significant difference between the two groups before treatment（P〉0.05）, 1, 4 and 8 weeks after treatment, and the observation group was significantly lower than that in control group（P〈0.05）. The incidence of adverse reactions was 31%, the control group was 28.6%, the difference between the two groups was not significant（P〉0.05）. Conclusions： Escitalopram combined with zolpidem in the treatment of primary can play a role in improving the quality of sleep in patients with insomnia and adverse reactions.