丹参酮ⅡA磺酸钠注射液治疗急性胰腺炎疗效观察

Effect of sodium tanshinon ⅡA silate injection on acute pancreatitis

目的探讨丹参酮ⅡA磺酸钠注射液治疗急性胰腺炎(AP)的临床效果。方法 65例AP患者分为观察组34例和对照组31例,2组患者均给予禁食、吸氧、胃肠减压、预防感染及早期肠内营养等常规治疗。在常规治疗的基础上,对照组患者给予乌司他丁10万u,静脉滴注,每日2次,1周为1个疗程,治疗2个疗程;观察组患者给予丹参酮ⅡA磺酸钠注射液40 mg,静脉滴注,每日1次,1周为1个疗程,治疗2个疗程。治疗结束后比较2组患者的治疗效果。结果观察组患者体温、腹痛、黄疸恢复时间及住院时间显著短于对照组(P<0.05)。治疗前2组患者血清淀粉酶、脂肪酶、空腹血糖水平及红细胞沉降率(ESR)比较差异均无统计学意义(P>0.05)。治疗后2组患者血清淀粉酶、脂肪酶、空腹血糖水平及ESR均显著低于治疗前(P<0.05)。治疗后观察组患者血清淀粉酶、脂肪酶、空腹血糖水平及ESR均显著低于对照组(P<0.05)。治疗第3、5、7、14天,2组患者白细胞(WBC)计数、血清C-反应蛋白(CRP)水平均显著低于治疗前及治疗第1天(P<0.05),观察组患者WBC计数、血清CRP水平均显著低于对照组(P<0.05)。结论丹参酮ⅡA磺酸钠可显著改善AP患者临床症状,恢复胰腺正常功能,减轻胰腺炎症反应,提高治疗效果。

Objective To investigate the effect of sodium tanshinon ⅡA silate injection on acute pancreatitis（ AP）.Methods Sixty-five patients with AP were divided into observation group（ n = 34） and control group（ n = 31）. The patients in the two groups were treated with fasting,oxygen inhalation,gastrointestinal decompression,infection prevention,early enteral nutrition and other conventional treatment. Based on the conventional treatment,the patients in control group were treated with ulinastatin 100 000 u by intravenous drip,twice a day for two courses of treatment,one week as a course of treatment; the patients in observation group were treated with sodium tanshinon ⅡA silate injection 40 mg by intravenous drip,once a day for two courses of treatment,one week as a course of treatment. The curative effect was compared between the two groups after treatment. Results The recovery time of body temperature,stomachache,jaundice and the hospitalization time in observation group were significantly shorter than those in control group（ P〈0. 05）. There was no significant difference in the level of serum amylase,lipase,fasting blood glucose and erythrocyte sedimentation rate（ ESR） between the two groups before treatment（ P〉0. 05）. The levels of serum amylase,lipase,fasting blood glucose and ESR after treatment were significantly lower than those before treatment in the two groups（ P〈0. 05）. The levels of serum amylase,lipase,fasting blood glucose and erythrocyte sedimentation rate in observation group were significantly lower than those in control group after treatment（ P〈0. 05）. The white blood cell（ WBC） and serum C-realtive protein（ CRP） level at the third,fifth,seventh and fourteenth day of treatment were significantly lower than those before treatment and at the first day of treatment（ P〈0. 05）. The WBC and serum CRP level in observation group were significantly lower than those in control group at the third,fifth,seventh and fourteenth day of treatment（ P〈0. 05）. Conclusion Sodium tanshinon ⅡA silate can significantly improve clinical symptoms,recover the function of the pancreas,reduce pancreatic inflammation and increase the effect of treatment in patients with AP.