抗菌药物不合理使用与药物不良反应发生的相关性

The Correlation between the Irrational Use of Antimicrobial Agents and the Occurrence of Adverse Drug Reactions

目的探讨抗菌药物不合理使用与药物不良反应发生的相关性。方法选取2013年1月至2014年11月云南省临沧市镇康县人民医院诊治的药物不良反应患者62例,收集患者临床资料,对其使用的抗菌药物类型、用药途径、不良反应发生及其表现形式、部位等进行统计分析。结果喹诺酮类药物引发的不良反应发生率最高,其次为β-内酰胺类抗生素;不良反应主要累及皮肤及软组织,其次为消化系统;抗菌药物不合理使用主要为用药时间过长、滴速过快、剂量过大、药液浓度过高;Person相关性分析结果显示,用药时间过长、滴速过快、剂量过大、药液浓度过高与抗菌药物的各不良反应发生均呈正相关。结论应用抗菌药物前应详细了解使用药物的适应证、禁忌证、可能出现的不良反应等,使用时合理控制药物的剂量和浓度、用药时间、输药速度,并加强医护双方监测,以减少不良反应的发生。

Objective To investigate the relationship between the irrational use of antibiotics and the occurrence of adverse drug reactions.Methods November January 2013 to 2014 Yunnan Province Lincang zhenkang County People＆#39;s Hospital for diagnosis and treatment of adverse drug reactions in patients with 62 patients were selected to col ect clinical data of the patients,to carry on the statistical analysis to the the use of antibacterial drug type,route of administration,adverse reactions occur rate and adverse reaction of form and location.Results Quinolone induced adverse reaction rate was the highest,fol owed by beta lactam antibiotics;adverse reactions mainly involving the skin and soft tissue.Secondly,for the digestive system;unreasonable use of antibacterial drugs mainly medication for a long time,speed too fast,the dose is too large,the high drug concentration;Pearson correlation analysis showed that,medi-cation for a long time,speed is too fast,excessive dosage,high drug concentration and antibacterial drugs,the adverse reactions were positively correlated.Conclusion In order to reduce the occurrence of adverse reactions,the use of antibiotics should be used to understand the use of drugs,the indications,the possible adverse reactions,and so on.