摘要
Small RNA（sRNA）-mediated post-transcriptional regulation differs from protein-mediated regulation. Through basepairing, sRNA can regulate the target m RNA in a catalytic or stoichiometric manner. Some theoretical models were built for comparison of the protein-mediated and sRNA-mediated modes in the steady-state behaviors and noise properties. Many experiments demonstrated that a single sRNA can regulate several m RNAs, which causes crosstalk between the targets.Here, we focus on some models in which two target mRNAs are silenced by the same sRNA to discuss their crosstalk features. Additionally, the sequence-function relationship of sRNA and its role in the kinetic process of base-pairing have been highlighted in model building.
Small RNA（sRNA）-mediated post-transcriptional regulation differs from protein-mediated regulation. Through basepairing, sRNA can regulate the target m RNA in a catalytic or stoichiometric manner. Some theoretical models were built for comparison of the protein-mediated and sRNA-mediated modes in the steady-state behaviors and noise properties. Many experiments demonstrated that a single sRNA can regulate several m RNAs, which causes crosstalk between the targets.Here, we focus on some models in which two target mRNAs are silenced by the same sRNA to discuss their crosstalk features. Additionally, the sequence-function relationship of sRNA and its role in the kinetic process of base-pairing have been highlighted in model building.
基金
Project supported by the National Basic Research Program of China(Grant No.2013CB834100)
the National Natural Science Foundation of China(Grant Nos.11121403 and 11274320)
the Open Project Program of State Key Laboratory of Theoretical Physics
Institute of Theoretical Physics
Chinese Academy of Sciences
China(Grant No.Y4KF171CJ1)
the National Natural Science Foundation for Young Scholar of China(Grant No.11304115)
the China Postdoctoral Science Foundation(Grant No.2013M541282)
