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度洛西汀治疗抑郁症后对血小板的影响 被引量：4

Assessment of the changes in platelet in the treatment of depression by duloxetine
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摘要 目的:探讨抑郁症患者经度洛西汀治疗前后血小板计数(PLT)和血小板平均体积(MPV)的变化及其意义。方法:31名女性抑郁症住院患者,接受度洛西汀单药治疗,观察治疗前及治疗6周后PLT及MPV变化。结果:经度洛西汀治疗6周后,患者MPV和PLT均显著下降(P<0.001)。结论:度洛西汀治疗可影响女性抑郁患者的PLT和MPV,MPV可反映血小板的活性,但其是否可以作为抑郁症诊断治疗的一个预测指标还需要进一步的研究。 Objective： To study the changes of platelet count（ PLT） and platelet mean volume（ MPV）,that before and after the treatment by duloxetine in patients with depression and its significance. Methods： 31 female patients with depression,was received a single drug treatment. In the treatment before and after 6 weeks of treatment,inspect for platelet count and platelet volume. Results：After 6 weeks of treatment,both PLT and MPV were significantly decreased（ P 0. 001）. Conclusion： A predictor of duloxetine can influence of PLT and MPV changes,MPV can reflect platelet activity,whether it can be as a depression diagnosis and treatment still need further research.
作者 鲁文波 申光范 李颖 甘莉艳
机构地区 吉林省延边脑科医院
出处 《中国药物滥用防治杂志》 CAS 2015年第6期336-338,共3页 Chinese Journal of Drug Abuse Prevention and Treatment
关键词 血小板计数 血小板体积 抑郁症 度洛西汀 platelet count platelet volume depression duloxetine
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献21

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二级参考文献24

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共引文献34

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中国药物滥用防治杂志
2015年 第6期

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