南阳市人乳头状瘤病毒分型感染调查

Survey on HPV subtype infections in Nanyang city

目的 调查分析南阳市女性HPV感染情况以及分型情况。方法 选择在南阳市中心医院进行妇科检查的1893例女性作为研究对象,对宫颈脱落细胞人乳头状瘤病毒（HPV）DNA基因分型进行检测,得出HPV的感染率和HPV分型情况。研究HPV分型与宫颈病变,HPV感染和HPV分型与年龄,HPV感染与怀孕次数、分娩次数以及流产次数之间的关系。结果 1 893例女性中,364例感染HPV,感染率为19.23%。其中HPV单一感染241例,占感染人数的66.21%;HPV双重感染59例,占感染人数的16.21%;HPV三重及以上感染16例,占感染人数的4.39%。HPV分型感染率最高的是HPV 16,其余依次为HPV 58、HPV 33、HPV 18、HPV 52等;HPV 16也是最容易导致宫颈癌前病变及宫颈癌的分型。〉45岁和〈30岁女性HPV感染率以及高危HPV分型的感染率均高于30-45岁女性,差异有统计学意义（P〈0.05）。多次妊娠和多次分娩是HPV感染的危险因素。近50%的HPV感染女性存在外伤史,最常见的是结扎手术。结论 南阳市女性HPV感染分型以HPV 16为主,年轻女性、中老年女性、有多次妊娠史和分娩史女性、有外伤史女性感染HPV的几率较高,需加强相关的筛查工作。

Objective To investigate and analyze the infection and subtypes of human papillomavirus （HPV） among the women in Nanyang city. Methods A total of 1 893 women receiving gynecological examination in the hospital were selected as research objects, HPV DNA genotypes of cervical exfoliated cells were detected. The relationships between HPV subtypes and cervical lesions, HPV infection and HPV classification and age, HPV infection and gravidity and abortion times were analyzed. Results Among 1 893 women, 364 women were found with HPV infection, the infection rate was 19. 23%, including 241 women with HPV single infection （66. 21% ）, 59 women with HPV double infection （ 16.21% ）, 16 women with HPV triple and more than triple infection （4. 39% ） . Among HPV subtypes, the infection rate of HPV 16 was the highest, followed by HPV 58, HPV 33, HPV 18, HPV 52, and so on; HPV 16 was also the most common subtype indu- cing cervical precancerous lesion and cervical cancer. The infection rates of HPV and high risk HPV subtypes among the women more than 45 years old and less than 30 years old were statistically significantly higher than those among the women aged 30-45 years old （P〈0. 05 ） . Multiple pregnancy and multiple delivery were the risk factors of HPV infection. There were nearly 50% HPV-infected patients with traumatic history, ligation was the most common type. Conclusion HPV 16 is the most common subtype of HPV infection among the women in Nanyang city. Young women, middle-aged women, women with multiple pregnancy and childbirth history, women with traumatic history are found with high incidence rate of HPV, the relevant work of screening should be strengthened.