核苷酸适体在靶向给药系统中的应用进展

Application progress of nucleic acid aptamers in targeted drug delivery system

适体,即体外合成筛选得到的能特异性地与靶分子结合的一段寡核苷酸序列。由于其独特的性质,在靶向给药系统中有着广阔的应用前景,目前已成为靶向给药研究领域的热点。综述了适体在靶向给药系统中的优势及其应用进展,并对其应用前景和面临的问题进行分析。

Aptamers are single stranded oligonucleotides that have high affinity and specificity towards a wide range of target molecules .Owing to the indispensable advantages ,aptamers have wildly prospects and have become a research hotspot in targeted drug delivery system （TDDS） .In this article ,application advantage and progress of aptamers in TDDS were briefly reviewed ,the problems and prospects were also discussed .