喹诺酮类抗菌药不良反应的研究进展

Research progress of adverse drug reaction of quinolone antimicrobial agents

喹诺酮类药物自开发以来由于其抗菌谱广、活性强而受到临床欢迎。其常见的不良反应包括:胃肠道紊乱、神经系统反应、皮肤反应等,大多程度轻微且可自愈。但某些品种上市后因严重的毒副作用而撤出市场,应当引起临床高度重视。笔者通过查阅国内外有关文献,总结其不良反应、发生不良反应的高危因素及在特殊人群中的应用,以期为临床合理用药提供参考。

Quinolones are widely used due to the wide antimicrobial spectrum and strong activity .The common adverse reactions of quinolones include gastrointestinal disturbances ,central nervous system reaction ,skin reaction ,etc .These adverse reactions are mild in severity and self-healing .Since some agents were withdrawn from the market due to severe adverse effects ,we should pay more attention to quinolones .Both internal and abroad literatures were reviewed ,the adverse effects , the high risk factors of the adverse effects and the application in special population were summarized to provide reference for ra-tional clinical drug use .