免疫球蛋白静脉注射治疗小儿重症肺炎的临床研究

Clinical Study of Intravenous Immunoglobulin in Treatment of Pediatric Severe Pneumonia

目的分析和探讨注射免疫球蛋白在小儿重症肺炎患者治疗过程中的价值和意义。方法按照随机双盲对照的原则抽取于2014年1月—2015年1月来该院就诊的180例小儿重症肺炎患儿作为研究对象并分为观察组和对照组,其中对照组和观察组各90例患者,对照组在治疗的过程中给予常规方案(吸氧、抗感染、抗病毒纠正酸碱失衡)治疗,而观察组患者则在应用上述方案的同时加用免疫球蛋白,对比和分析两组治疗效果。结果观察组患者的总有率达96.67%,显著高于对照组86.67%,经过对比分析发现,对照组患儿的临床治疗效果和观察组患儿的相比明显降低,两组比较差异有统计学意义(P<0.05)。观察组患儿发热、咳嗽、肺部啰音、胸片炎症消失时间分别为(3.46±1.11)d、(8.08±3.23)d、(6.87±3.21)d、(8.76±0.65)d,对照组患儿分别为(2.13±1.01)d、(5.50±1.44)d、(4.80±1.41)d、(6.17±0.40)d,对照组患儿症状缓解时间明显多于观察组,且两组比较差异有统计学意义(P<0.05)。结论在常规药物治疗的基础上加用免疫球蛋白治疗小儿重症肺炎,不仅可以显著提高患者病情的临床治疗有效率,而且预防了各种不良事件的发生率,值得推广和应用。

Objective To explore the value of intravenous immunoglobulin in the treatment of pediatric severe pneumonia. Methods 180 patients with pediatric severe pneumonia admitted in our hospital during January 2014 and January 2015 were randomly selected as the research object and divided into observation group（n=90） and control group（n=90）. Patients in the control group were given conventional treatment（oxygen inhalation, anti-infection, antivirus, remeding acid-base unbalance） based on which those in the observation underwent intravenous immunoglobulin. The treatment effects were analyzed and compared between the two groups. Results There was statistically significant difference in total effective rate between the observation group and the control group, 96.67% vs 86.67%,P〈0.05. In disappearance time of fever, cough, pulmonary rales, inflammation seen on chest X-ray,the observation group were（3.46 ±1.11）d,（8.08 ±3.23）d,（6.87 ±3.21）d,（8.76 ±0.65）d, while those of the control group were（2.13 ±1.01）d,（5.50±1.44）d,（4.80±1.41）d,（6.17±0.40）d, and the differences were statistically significant,P〈0.05. Conclusion Intravenous immunoglobulin is worthy of promotion in the treatment of pediatric severe pneumonia due to its ability in improving the efficacy and reducing the adverse reaction.