乳酸菌素联合乳果糖治疗轻微型肝性脑病疗效分析

Efficacy of Lactic Acid Bacteria Therapy Combined with Lactulose for the Treatment of Minimal Hepatic Encephalopathy

目的通过乳酸菌素联合乳果糖对轻微型肝性脑病患者进行治疗,对其疗效进行观察和分析。方法整群选择2013年1月—2014年6月该院收治的68例轻微性肝性脑病患者,随机将患者分为观察组34例和对照组34例,对照组34例在常规治疗的基础上每天服用3次乳果糖,每次服用10 m L;观察组34例在对照组的治疗基础上每天服用2次乳酸菌素3次,每次服用0.33 g,对比两组患者的治疗效果。结果观察组与对照组治疗1个月后的数字连接试验及血案水平比较,差异均具有统计学意义,P<0.05。结论乳酸菌素联合乳果糖对轻微型肝性脑病患者进行治疗,可以使患者的血氨、内毒素得到有效降低,同时使数字连接时间得到减少,最终有效降低肝性脑病的发病率,值得在临床治疗中进行广泛应用。

Objective To analyze and observe the treatment effect of lactic acid bacteria therapy combined with lactulose for the treatment of minimal hepatic encephalopathy. Methods 68 patients with minimal hepatic encephalopathy admitted to our hospital between January 2013 and June 2014 were randomly divided into observation group and control group, 34 cases in each group. Pa-tients in the control groups underwent 10ml one time, 3 times one day of oral administration of lactulose on the basis of conven-tional treatment; while those in the observation group were given 0.33g one time, 3 times one day of oral administration of lactic acid bacteria based on the method used in the control group. The treatment effect of the two groups were compared. Results There were statistically significant differences between the results of the number connection test and blood ammonia levels of the two groups 1 month after treatment, P〈0.05. Conclusion Lactic acid bacteria combined with lactulose for the treatment to patients with minimal hepatic encephalopathy, can effectively lower the level of blood ammonia and endotoxin and shorten the time of number connection thus reduce the incidence of hepatic encephalopathy, therefore it is worthy of an extensive application in the clinical treatment.