慢性萎缩性胃炎患者消化内科临床治疗分析

Analysis of Clinical Treatment for Patients with Chronic Atrophic Gastritis Digestion in Department of Internal Medicine

目的探讨消化内科慢性萎缩性胃炎临床治疗方法及效果。方法随机选取慢性萎缩性胃炎80例,均为该院消化内科2013年1月—2014年1月收治,随机分组,就养胃冲剂单用(对照组,n=40)与加用枸橼酸铋钾、阿莫西林、克拉霉素三联疗法(观察组,n=40)效果进行比较。结果观察组选取病例经统计示临床总有效率为92.5%,对照组经统计示为62.5%,两组比较差异有统计学意义(χ2=8.924,P=0.017);观察组患者中发生1例呕吐和1例消化不良,对照组患者中发生3例呕吐、3例恶心以及4例消化不良,观察患者不良反应发生率明显低于对照组,两组比较差异有统计学意义(χ2=4.8039,P=0.2840)。结论依据慢性萎缩性炎患者临床特点,在明确诊断的基础上,取枸橼酸铋钾、阿莫西林、克拉霉素三联疗法应用,可使临床效果显著增强,安全性居较高水平,显著改善疾病预后,使患者生存质量在一定程度上改善,在临床有较高的应用价值,值得广泛推广。

Objective To investigate clinical treatment for patients with chronic atrophic gastritis digestion in Department of Inter-nal Medicine. Methods 80 patients with chronic atrophic gastritis admitted to the Department of Gastroenterology of our hospital from January 2013 to January 2014 were randomly divided into control group （n=40）and observation group（n=40）. Yangwei Medici-nal Instant Granules was used in the control group, while the bismuth potassium citrate ,amoxicillin and clarithromycin triple ther-apy was additionally used in the observation group. The effect was compared between the two groups. Results The statistical pro-cessing revealed that clinical efficacy rate of the observation group was 92.5% and that of the control group was 62.5%, and the difference was statistically significant（χ2=8.924,P=0.017）;There were 1 cases of vomiting, 1 cases of indigestion in the observation group and 1 cases of vomiting, 3 cases of nausea and 4 cases of indigestion in the control group, and the difference was statisti-cally significant （χ2=4.8039,P=0.2840）. Conclusion Based on the clinical features of patients with chronic atrophic inflammation and clear diagnosis, the bismuth potassium citrate, amoxicillin, clarithromycin triple therapy can significantly enhance the clinical effects and significantly improve prognosis of the disease safety. With higher safety and clinical application value, it can also im-prove the quality of life of patients to some extent, so it is deserves widespread recommendation.