慢性鼻窦炎鼻息肉合并支气管哮喘患者鼻窦内镜手术对支气管哮喘疗效的影响分析

Effect of Endoscopic Sinus Surgery on Bronchial Asthma in Patients with Chronic Sinusitis and Nasal Polyps

目的探讨鼻窦内镜技术对慢性鼻窦炎合并支气管哮喘患者的发作影响。方法选取该院在2008年1月—2013年1月收治的50例慢性鼻窦炎鼻息肉患者,50例慢性鼻窦炎鼻息肉合并支气管哮喘患者,50例健康正常组。对3组进行s CD23、s IL-2R、IL-4指标对比,鼻窦内镜手术对慢性鼻窦炎鼻息肉合并支气管哮喘对支气管哮喘疗效的影响。结果与术前相比,鼻窦炎组、合并哮喘组术后的s CD23、s IL-2R、IL-4水平显著降低,IFN-γ水平显著升高(P<0.05);50例合并支气管哮喘患者,发作次数减少31例(62.0%),发作次数无变化28例(56.0%),次数增加1例(2.0%)。结论鼻窦内镜手术治疗慢性鼻窦炎鼻息肉合并支气管哮喘患者,可调节患者的s CD23、s IL-2R、IFN-γ、IL-4水平,使哮喘的发作频率大为降低,远期疗效确切,值得在临床上推广应用。

Objective To observe the effect of endoscopic sinus surgery on the seizure frequency of bronchial asthma in patients with chronic sinusitis and nasal polyps . Methods 50 patients with chronic sinusitis and nasal polyps, 50 with chronic sinusitis and nasal polyps combined with bronchial asthma, 50 healthy persons, all of whom were admitted to our hospital between January 2008 and January 2013, were selected. Indicators of sCD23,sIL-2R IL-4 were compared between the three groups. Effect of endo-scopic sinus surgery on the seizure frequency of bronchial asthma in patients with chronic sinusitis and nasal polyps was investi-gated. Results The sCD23, sIL-2R, IL-4 levels of chronic the sinusitis and nasal polyps groups and the chronic sinusitis and nasal polyps combined with bronchial asthma groups after operation were obviously lower than that before operation, while the IFN-γlevels were obviously higher; Of all 50 patients with chronic sinusitis and nasal polyps combined with bronchial asthmacas-es ,seizure frequency of 31 （62.0%） cases reduced, 28 cases（56.0%）remained unchanged and 1 cases increased （ 2.0%） . Con-clusion For bronchial asthma in patients with chronic sinusitis and nasal polyps,Endoscopic sinus surgery can adjust the sCD23,sIL-2R,IFN-γ,IL-4 levels and greatly reduce the seizure frequency of asthma. With long-term efficacy, it deserves further clin-ical applications.