比索洛尔与美托洛尔治疗高血压伴慢性心力衰竭的临床研究

Observation on effect of bisoprolol and metoprolol in the treatment of hypertension with chronic heart failure

目的:探讨比索洛尔与美托洛尔治疗高血压伴慢性心力衰竭的疗效。方法:将高血压伴慢性心力衰竭患者80例随机分为观察组和对照组,对照组给予美托洛尔治疗,观察组给予比索洛尔治疗,评估两组临床治疗效果及安全性。结果:观察组患者高血压总有效率明显高于对照组,两组比较,差异具有统计学意义(P<0.05)。观察组患者心功能总有效率与对照组比较,差异无统计学意义(P>0.05)。观察组SBP及DBP明显优于对照组,两组比较,差异具有统计学意义(P<0.05)。观察组LVEDD及EF与对照组比较差异无统计学意义(P>0.05)。结论:比索洛尔降压效果更好,在改善心功能方面疗效相当。

Objective To investigate the effect of bisoprolol and metoprolol in the treatment of hypertension with chronic heart failure. Method 80 cases with hypertension with chronic heart failure were divided into the observe group and the control group. The control group received the metoprolol treatment,and the observe group received the bisoprolol treatment. The clinical efficacy and safety of two groups were evaluated. Results The hypertension total rate in the observe group was more than those in control group,the difference was statistically significant（ P〈0. 05）. The Heart function total rate in the observe group was same to those in ontrol group,the difference wasn＇t statistically significant（ P〉0. 05）. The SBP and DBP in the observe group was superior to that in control group,the difference was statistically significant（ P〈0. 05）. The LVEDD and EF in the observe group was same to those in ontrol group,the difference wasn＇t statistically significant（ P〉0. 05）. Conclusion The effect of bisoprolol in the treatment of hypertension is better,and the effect of bisoprolol in the treatment of chronic heart failure is same to that of bisoprolol.