摘要
目的探讨大鼠肝纤维化中大黄蛰虫胶囊对基质金属蛋白酶-2(MMP-2)活性的影响。方法采用明胶酶谱法检测肝组织MMP-2活性,采用天狼猩红染色法判断肝纤维化程度。结果随着肝纤维化程度的加重,大黄蛰虫胶囊组MMP-2活性升高幅度明显低于模型组(P<0.05),但高于空白组(P<0.05)。结论大黄蛰虫胶囊可能通过降低MMP-2活性抑制大鼠肝纤维化发展。
Objective To investigate the effect of Dahuangzhechong capsule on matrix inetaUoproteinase-2 （MMP-2） activity in rats with hepatic fibIvsis. Methods The collagen deposition and MMP-2 activity in the liver tis- sues were detected by Sirius red staining .and zymography respectively. Results With the severity of liver fibrosis, the rising of MMP-2 activity in Dahuangzhechong capsule group was significantly lower than that in the liver fibrosis model group （P 〈 0.05 ）, but greater than ttlat in tile control group （P 〈 0.05 ）. Conclusion Dahuangzhechong capsule has a depressant effect on MMP-2 activity and inhibits the development of hepatic fibrosis in rats.
出处
《中国临床新医学》
2015年第11期1036-1038,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
