美沙拉嗪治疗溃疡性结肠炎的效果研究

Study on Treatment Effect of Mesalazine for Ulcerative Colitis

目的：研究美沙拉嗪治疗溃疡性结肠炎的临床效果。方法选取2014年5月～2015年5月我院接收的溃疡性结肠炎患者70例。随机分成对照组和实验组，给予实验组美沙拉嗪药物治疗，给予对照组柳氮磺胺吡啶治疗，8周作为一个疗程。结果对照组采用柳氮磺胺吡啶治疗的总有效率是80%，实验组采用美沙拉嗪治疗的总有效是96%，实验组的总有效率高于对照组，而实验组出现的不良反应低于对照组，差异有统计学意义（P＜0.05）。结论美沙拉嗪治疗溃疡性结肠炎疗效显著，安全性高。

ObjectiveClinical effect of mesalazine in treatment of ulcerative colitis is to be studied. Methods 70 patients of ulcerative colitis who are treated in hospital from May 2014 to May 2015 and separate them into control group and study group at random, patients in study group are given mesalazine treatment and patients in control group are given sulfasalazine treatment, and take 8 weeks as a course of treatment.Results Patients’ treatment efifcacy in control group is 80%, which is lower than 96% in study group, besides, patients’ side-effect incidence in study group is less than that in control group, there is a differential between two groups and such a differential has statistic value （P〈0.05）.Conclusion Clinical efficacy and safety of mesalazine in treatment of ulcerative colitis is remarkable.