恩替卡韦在慢性乙肝患者中的临床疗效观察

Clinical Efficacy of Entecavir in Patients With Chronic Hepatitis B

目的：探讨恩替卡韦在慢性乙肝患者中的临床治疗效果。方法选取2014年4月～2015年4月我院诊治的96例慢性乙肝患者资料进行分析，采用随机数字方法将患者分为对照组和观察组，对照组采用常规综合治疗方法，观察组在综合治疗的基础上加服恩替卡韦，在进行6个月的治疗后，比较两组临床治疗效果。结果观察组治疗有效率（75%）高于对照组（41.7%）（P＜0.05）；观察组乙肝病毒转阴率也比对照组高（P＜0.05）；观察组无患者发生不良反应（P＜0.05）。结论恩替卡韦治疗慢性乙型肝炎疗效显著，安全性高。

Objective To investigate the clinical effects of entecavir in chronic hepatitis B patients.Methods From April 2014 to April 2015, 96 cases of chronic hepatitis B patients in our hospital patient data were analyzed using a random number method Patients were divided into control group and observation group, the control group received routine treatment, we observed after the group took on the basis of comprehensive treatment entecavir, during six months of treatment, clinical outcomes were compared. Results The treatment efifciency （75%） was signiifcantly higher （41.7%） （P〈0.05）, observation group HBV seroconversion rate is higher than the control group （P〈0.05）, There were no observed adverse patient The reaction （P〈0.05）.Conclusion Entecavir in treatment of chronic hepatitis B patients is with signiifcant, and safe.