关节腔注射肿瘤坏死因子拮抗剂与注射甲氨蝶呤治疗类风湿关节炎对比观察

Articular Cavity Injection of Tumor Necrosis Factor Antagonists and Methotrexate Injection to Treat Rheumatoid Arthritis

目的：比较关节腔注射肿瘤坏死因子拮抗剂与注射甲氨蝶呤针剂治疗类风湿关节炎的临床效果。方法随机抽取2012年2月～2015年2月在我院接受治疗的100例类风湿关节炎患者作为观察对象，根据治疗方法将患者随机分为两组，1组患者实施关节腔注射肿瘤坏死因子拮抗剂（依那西普）疗法，2组患者接受关节腔注射甲氨蝶呤针剂治疗，比较两组疗效。结果两组患者治疗期间，不良反应发生率未出现明显差异（P＞0.05）；1组总有效率高于2组，且1组治疗后关节活动程度、关节炎缓解程度优于2组，两组差异显著（P＜0.05）。结论关节注射肿瘤坏死因子拮抗剂（依那西普）与注射甲氨蝶呤针剂均能够对类风湿关节炎患者发挥较好的治疗效果，且均会导致患者出现不同程度不良反应。但是，关节注射肿瘤坏死因子在关节活动程度及关节炎缓解程度上更具优势。

Objective Compare the articular cavity injection of tumor necrosis factor antagonists and methotrexate injection for treatment of rheumatoid arthritis.Methods Randomly in February 2012 to February 2015 in our hospital for treatment of 100 patients with rheumatoid arthritis as research object, according to treatment the patients were randomly divided into two groups, one group of patients implement articular cavity injection of tumor necrosis factor antagonists （according to the heap） treatment, 2 groups of patients with articular cavity injection of methotrexate injection treatment, compared two groups of curative effect. ResultsTwo groups of patients during treatment, the incidence of adverse drug reactions does not appear obvious difference （P〉0.05）, 1 group total effective rate was obviously higher than 2, and 1 set of joints, arthritis relieved after treatment was significantly better than 2 group, significant difference was found in two groups （P〈0.05）.Conclusion Joint injection of tumor necrosis factor antagonists （etanercept） and methotrexate injectionnbsp;can play a good therapeutic effect in patients with rheumatoid arthritis, and will lead to different degree of adverse reactions to patients. But, joint injection of tumor necrosis factor in relief extent joint activity degree and arthritis.