鹤山地区HPV基因型别分布调查情况分析

Distribution of Human Papillomavirus Genotypes among Women Registered in Heshan

目的调查广东省鹤山市户籍人群人乳头瘤病毒（HPV）感染状况,分析HPV型别和年龄分布特征。方法利用飞行时间质谱技术/二代高通量测序技术对8966例女性户籍人口进行14种高危型HPV和2种低危型HPV基因分型检测。结果检出HPV总阳性率为6.3%,HPV检出率前3位型别分别是HPV52（22.35%）、HPV16（12.34%、HPV58（10.45%）。35~44岁年龄组检出率最高。比较各年龄段HPV检出率,差异有统计学意义（P〈0.05）。在CIN2/3中HPV检出率前3位型别分别是HPV33（29.03%）、HPV16（27.54%、HPV58（15%）。结论鹤山市户籍人口HPV感染较高的型别为HPV52、16、58,HPV33感染率虽较低,致癌性比较强。

Objective To investigate human papillomavirus（HPV）genotype distribution in Heshan city Guangdong province and analyze the characteristics of HPV type and age. Methods 14 high risk HPV genotypes and 2 low risk HPV genotypes of 8966 registered women were detected by time of flight mass spectrometry technology/second generation high-throughput sequencing technologies.Results HPV positive rate was 6.3%.Among HPV infection,HPV52 was the most common genotype（22.35%）,followed by HPV16（12.34%）,and HPV58（10.45%）.Women in the 35~44 age groups were the highest HPV positive population. There are statistical differences between age groups（P〈0.05）. The top three HPV types in CIN2/3 were HPV33（29.03%）、HPV16（27.54%、HPV58（15%）. Conclusion The common HPV infection types in registered women of Heshan were HPV52、16、58. HPV33 infection rate was low relatively, but with high carcinogenicity.