自噬在急性胰腺炎中作用的研究进展

Research progress on the role of autophagy in acute pancreatitis

急性胰腺炎是由多种病因引起酶原激活,从而导致胰腺组织自我消化,进而水肿、出血甚至坏死的急性炎症性疾病。自噬,又被称为Ⅱ型程序型死亡,是机体细胞清除多余或损伤的细胞器以及为细胞代谢提供必需能量和营养物质的一种重要方式。自噬在胰腺炎的发生发展过程中扮演重要角色。本文就自噬来源、自噬与酶原激活的关系及自噬在胰腺炎发生发展过程中的作用作一综述。

Acute pancreatitis is a zymogen activation by a variety of causes, which lead to self digestion of pancreatic tissue, inflammation and edema, hemorrhage and necrosis. Autophagy, also known as the II program death, is a way to remove excess or injury organelles and provide an important way of energy and nutrients necessary for cell metabolism. Autophagy plays an important role in the occurrence and development process of pancreatitis. In this paper, the relationship between autophagy and autophagy source of zymogen activation of autophagy in the occurrence and development of acute pancreatitis and the role in the process were reviewed.