氨基酮戊酸光动力疗法治疗皮肤癌前病变及浅表皮肤癌的临床疗效探讨

Clinical curative effect observation on ALA-PDT in the treatment of skin lesions and superficial skin cancer before

目的探讨氨基酮戊酸光动力疗法治疗皮肤癌前病变及浅表皮肤癌的临床疗效。方法选取该院皮肤科2011年3月—2014年6月间就诊的皮肤癌前病变及皮肤浅表癌患者60例,对其采用氨基酮戊酸光动力疗法治疗,然后观察其临床疗效及不良反应。结果日光性角化及疣状癌的总有效率为100%,基底细胞癌的总有效率为95.2%,鳞癌的总有效率为85.7%,鲍温病的总有效率为14.3%,pa的总有效率为88.9%,不同类型疾病之间的疗效相比,差异无统计学意义(P>0.05)。经过半年的随访,发现患者容易出现复发现象,疣状癌的复发率为25%,日光性角化疾病的复发率为20%,鳞癌的复发率为14.3%,鲍温病的复发率为14.3%,基底细胞癌的复发率为14.2%,Paget病的复发率为11.1%,通过对各疾病之间复发率进行统计分析可知,差异无统计学意义(P>0.05),且不良反应较轻。结论应用氨基酮戊酸光动力疗法治疗皮肤癌前病变及浅表皮肤癌,临床疗效较好、无痛苦、患者较为满意,具有临床应用推广价值。

[Abstact] Objective Discuss the clinical curative effect observation on ALA-PDT in the treatment of skin lesions and superficial skin cancer before.Methods Select superficial lesion before visits between skin cancer and skin cancer patients with 60 cases of our hospital dermatological department in March 2011 to June 2014,and observe the clinical curative effect and adverse reactions. Results The solar sex Angle and verrucous carcinoma of the total effective rate was 100%,the total effective rate was 95.2% of basal cell carcinoma, squamous cell carcinoma of the total effective rate was 85.7%, bao warm disease the total effective rate was 14.3%, pa of the total effective rate was 88.9%, the curative effect between different types of diseases compared with no statistical-ly significant difference （P〉0.05）. After six months of follow-up, found patients prone to recurrent phenomenon, verrucous carcino-ma recurrence rate was 25%, the Angle of solar sex disease recurrence rate was 20%, and squamous cell carcinoma recurrence rate was 14.3%, the bao of warm disease recurrence rate was 14.3%, basal cell carcinoma recurrence rate was 14.2%, Paget＆#39;s dis-ease recurrence rate was 11.1%, through the study of the statistical analysis of various disease recurrence rates between, there was no statistically significant difference （P〉0.05）, and the adverse reaction is lighter.Conclusion ALA-PDT has satisfactory effects in the treatment of skin lesions and superficial skin cancer before,The clinical curative effect is better, patients have no more pain and been satisfacted,it has the clinical application promotion value.