摘要
目的探讨幽门螺杆菌(Hp)阳性糜烂性胃炎进行抗生素与不同质子泵抑制剂三联疗法的临床效果。方法随机选取该院2013年6月—2014年5月收治的120例Hp阳性糜烂性胃炎患者,根据随机数字表法分为A组、B组、C组,每组40例,所有患者均予以克拉霉素与阿莫西林,A组加用埃索美拉唑,B组加用奥美拉唑,C组加用兰索拉唑,3组均治疗1个月,对比3组在治疗后治疗后比较3组的临床有效率、幽门螺杆菌(HP)根除率以及和复发发生率。结果 A组的临床有效率为90.0%,显著高于B组、C组的55.0%、52.5%,差异有统计学意义(P<0.05),B、C两组之间比较对比差异无统计学意义(P>0.05);A组的HP根除率及复发率显著明显优于B、C组,差异有统计学意义(P<0.05),而但B、C两组之间比较对比差异无统计学意义(P>0.05)。结论埃索美拉唑与抗生素三联疗法对于治疗Hp阳性糜烂性胃炎效果显著,对幽门螺杆菌抑制强,复发率低,值得临床应用及推广。
Objective To observe the clinical effects of antibiotics and different PPI triple therapy for HP positive erosive gastritis. Methods 120 patients with HP positive erosive gastritis treated from June 2013 to May 2014 in our hospital were selected and randomly divided into Group A, Group B and Group C, 40 cases each group. All the patients took CLA and Amoxicillin. On the basis, Group A took Esomeprazole; Group B took OME; Group C took Lansoprazole; after 1m of treatment, the clinical effective rate, eradication rate of HP and recurrence rate of three groups were compared. Results The effective rate of Group A （90.0%） was significantly higher than that of Group B （55.0%） and Group C （52.5%） （P〈0.05）; the effective rate of Group B and Group C was not significantly different （P〉0.05）. The eradication and recurrence rate of HP of Group A was significantly better than that of Group B and Group C （P〈0.05）. The rate of Group B and Group C was not significantly different （P〉0.05）. Conclusion For HP positive erosive gastritis, Esomeprazole and antibiotics triple therapy have an obvious treatment effect and a lower recurrence rate in effectively controlling HP. It is worthy of clinical application and promotion. .
出处
《中外医疗》
2015年第13期38-39,共2页
China & Foreign Medical Treatment
