序贯方案和标准三联方案治疗初始幽门螺旋菌感染患者的临床比较

Clinical Comparison of Sequential Scheme and Standard Triple Therapy in Treatment of Initial Patients with Infection of Helicobacter Pylori

目的比较序贯方案和标准三联方案治疗初始幽门螺旋菌感染临床疗效。方法以该院于2012年3月—2014年9月共收治106例符合要求初始幽门螺旋菌感染患者进行研究,分为两组。对照组采取三联疗法,观察组采取序贯疗法,比较两组临床症状评分、Hp根除率及不良反应发生率。结果观察组治疗结束、复查时的症状评分均显著低于对照组(P<0.05)。观察组根除率显著高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论序贯方案Hp根除率高,复发率低,有临床推广价值。

Objective To study the clinical effect of sequential scheme and standard triple therapy in treatment of initial patients with infection of Helicobacter pylori. Methods From 2012 March to 2014 September were treuted 106 cases who meet the re-quirements of initial Helicobacter in our hospital were divided into two groups. The control group took the triple therapy, observa-tion group adopted sequential therapy, comparison of two clinical symptom score, Hp eradication rate and the incidence of adverse reactions. Results The observation group after treatment, review the symptom scores were significantly lower than those in control group （P〈0.05）. The observation group the eradication rate was significantly higher than the control group （P〈0.05）; the incidence of adverse reactions of two groups had no significant difference （P〉0.05）. Conclusion Sequential scheme of Hp eradication rate, low recurrence rate, it has clinical value.