中药治疗溃疡性结肠炎脾虚湿困型疗效观察

目的:观察中药内服灌肠治疗溃疡性结肠炎(UC)脾虚湿困型的临床疗效。方法:68例随机分为两组,研究组34例给予参苓白术散加减内服配合中药灌肠,对照组34例口服美沙拉嗪,两组疗程均为1个月。结果:总有效率研究组97.06%、对照组76.47%,两组比较差异有统计学意义(P<0.05)。治疗后两组中医症状及结肠镜黏膜病变明显改善,且研究组改善更加明显(P<0.05)。治疗后两组IL-17、IL-23及TNF-α明显降低,且研究组降低更加明显(P<0.05)。随访1年,复发率研究组5.88%,对照组23.53%,两组比较差异有统计学意义(P<0.05)。结论:中药内服灌肠治疗UC脾虚湿困型疗效显著,可减少炎性反应,促进肠道黏膜的修复。

Objective： To observe the clinical therapeutic effect of herbal oral administration and enema in the treatment of ulcerative colitis （UC） of dampness stagnancy due to spleen asthnia type. Method： 68 cases were divided into 2 groups in random. 34 cases were treated by Modified Shenling Baichu Powder by oral administration combined with herbal enema as the study group while 34 cases were treated with Mesalazine by oral administration as the control group. Both groups were treated for 1 month. Result： The total effective rate of the study group was 97.06% while that of the control group was 76.4%. There was statistical significance between the two groups （P〈0.05）. After the treatment, TCM symptoms and colonic mucosal lesions of both groups improved significantly and the improvement of the study group was more significant （P〈0.05）. After the treatment, the level of IL-17 IL-23 and TNF- α decreased significantly and the improvement of the study group was more significant （P〈0.05）. With a follow-up of 1 year, the recurrence rate of the study group was 5.88% while that of the control group was 23.53%. There was statistical significance between the two groups （P〈0.05）. Conclusion： It has significant therapuetic effect that herbal oral administration and enema in the treatment of UC of dampness stagnancy due to spleen asthnia type, which could decrease inflammatory reaction and promote the repairment of intestinal mucosa.