6Koizumi W,Toma H, Watanabe K, et al. Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients,starting with 5 mg tablets[ J ]. Jpn J Clin 0ncol,2004,34:608 - 14.
7Mandema JW, Kaiko RF, Oslllack B, et al. Characterization and validation of a pharmacokinefic model for controlled-release oxycodone [ J]. BrJ Clin Pharmacol, 1996,42(6) :747 -6.
8Bruera E, Belzile M ,Pimskin E,et al. Randomized,double - blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain[J]. J Clin Onco1,1998,16(10) :3222 -3.
9孙燕,肿瘤内科学[M].2版.北京:人民卫生出版社,2003:232—3.
10Ackerman S J, Mordin M. Patient-reported utilization patterns of fentanyl transdermalsystem and oxyeodone hydrochloride controlled-release among patients with chronic nonmalignant pain [J]. J Manag care pharm ,2003,9 ( 3 ) :223 - 31.
2Choi YS, Billings JA. Opioid antagonists : a review of their role in Choi YS, Billings JA. Opioid antagonists : a review of their role in palliative care, focusing on use in opioid-related constipation [ J ]. J Pain Symptom Manage, 2002,24( 1 ) :71-90.
3Droney J, Ross J, Gretton S, et al. Constipation in cancer patients on morphine[ J]. Support Care Cancer, 2008,16(5) :453-459.
4LeBlanc TW, Abernethy AP. Palliative care and oncology: integration leads to better care [ J ]. Oncology ( Williston Park ), 2011,25(13) :1275.
5Youssef NN, Di Lorenzo C. Childhood constipation : evaluation and treatment [ J ]. J Clin Gastroenterol, 2001,33 (3) : 199-205.
6Choi YS, Billings JA. Opioid antagonists : a review of their role in palliative care, focusing on use in opioid-related constipation [ J ]. J Pain Symptom Manage, 2002,24 ( 1 ) : 71-90.
7Caraceni A, Hanks G, Kaasa S, et al. Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC[J]. Lancet Oncol, 2012, 13(2) :e58-e68.
8Emmanuel AV, Mason H J, Kamm MA. Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder[ J]. Gut, 2001,49 (2) : 209-213.
