慢性肾功能不全患者CYFRA21-1水平与肾功能指标的相关性分析

Correlation Between the Level of CYFRA21-1 and Renal Function Index in Patients with Chronic Renal Failure

目的分析慢性肾功能不全患者血清中CYFRA21-1水平与肾功能有关指标的相关性,探讨CYFRA21-1在慢性肾功能不全患者血清中的表达及临床意义。方法选取在我院进行健康体检者50人作为健康对照组;选取在我院肾脏内科住院的慢性肾功能不全患者50人作为慢性肾功能不全组,本组中再根据是否进行透析分为透析组(29人)和未透析组(21人),每组均抽血检测血清中CYFRA21-1、Cys-C和肌酐的浓度,并进行相关性分析。结果慢性肾功能不全患者CYFRA21-1、Cys-C、肌酐水平均明显高于健康对照组(P<0.01);透析组与未透析组之间CYFRA21-1和Cys-C水平无显著差异(P>0.1);透析组CYFRA21-1与Cys-C水平呈正相关(r=0.61,P<0.05),与肌酐水平无相关性;未透析组CYFRA21-1与Cys-C(r=0.63,P<0.05)和肌酐(r=0.59,P<0.05)水平呈正相关。结论慢性肾功能不全患者CYFRA21-1水平较正常人明显升高,且与Cys-C水平有一定相关性,可能与肾小球滤过功能减退和肾脏的代谢异常有关。

Objective To analysis the correlation between the level of CYFRA21-1 and renal function index in patients with chronic renal failure and to discuss the expression of CYFRA21-1 and its clinical significance.Methods 50 patients with chronic renal failure and 50 healthy volunteers were involved in this study. The patients group divided into dialysis group（ 29 cases） and non-dialysis group（ 21 cases）. The serum levels of CYFRA21-1,Cystatin-C and creatinine in patients and healthy controls were detected. Results The serum levels of CYFRA21-1,Cys-C and creatinine in patients with chronic renal failure were significantly higher than those in healthy controls（ P 〈0. 01）. There was no significant difference in CYFRA21-1 levels and Cys-C level between dialysis group and non-dialysis group（ P〉 0. 1）. The CYFRA21-1 level was positively correlated with Cys-C in dialysis group（ r = 0. 61,P 〈0. 05）,and no correlation with creatinine level. The CYFRA21-1 level was positively correlated with Cys-C level（ r = 0. 63,P〈 0. 05） and creatinine（ r = 0. 59,P 〈0. 05） in nondialysis group. Conclusion The serum CYFRA21-1 levels in chronic renal failure patients are significantly increased and positively correlated with Cys-C levels. This result may be relevant to reduced glomerular filtration function and abnormal renal metabolism.