2,4-二氯氟苯的合成研究进展

Advances in the Synthesis of 2,4-Dichlorofluorobenzene

介绍了国内外关于2,4-二氯氟苯的合成技术进展,按使用初始原料的不同对合成2,4-二氯氟苯的方法进行分类叙述。认为近年来作为环丙沙星、诺氟沙星等氟喹诺酮类抗生素的重要中间体2,4-二氯氟的需求量也在逐年增加,因此应紧密跟踪当前2,4-二氯氟苯的研究状况,并对现有的各种合成工艺路线进行深入研究与分析,加强对其开发研究。

Introduced the technology progress of the synthesis of 2,4-dichlorofluorobenzene domestic and foreign, and made classified narration according to the different starting materials. 2,4-Dichlorofluorobenzene is an important intermediate for the synthesis of fluoroquinolones antibiotics such as ciprofloxacin, norfloxacin etc, whose demand increased year by year, therefore we should closely track the current research status, and made research and analysis of all kinds synthesis process route in-depth, then strengthened its development research.