甲状腺癌患者外周血CEACAM1水平及其临床意义

Peripheral blood level of CEACAM1 in patients with thyroid cancer and its clinical significance

目的:探讨癌胚抗原黏附分子1(CEACAM1)在甲状腺癌患者外周血中水平及其对甲状腺癌的诊断价值。方法:用ELISA法检测76例甲状腺癌患者、48例甲状腺良性肿瘤患者和38例健康体检者外周血中CEACAM1水平,同时检测所有入组样本的癌胚抗原(CEA)及甲状腺球蛋白(TG)水平,分析外周血CEACAM1水平与甲状腺癌临床病理特征的关系,制作ROC曲线,比较CEACAM1、CEA、TG对甲状腺癌的诊断价值。结果:甲状腺癌患者血清CEACAM1水平明显高于甲状腺良性肿瘤患者及健康对照者(547.11 ng/mL vs.469.77 ng/mL、369.04 ng/mL,均P<0.05)。血清CEACAM1水平与甲状腺癌的TNM分期和淋巴结转移有关(均P<0.05)。血清CEACAM1水平诊断甲状腺癌的ROC曲线下面积为0.94,敏感性97.4%,特异性80.3%,CEACAM1对甲状腺癌的诊断价值优于CEA和TG。结论:血清CEACAM1检测对甲状腺癌的诊断及其病情评估有一定意义。

Objective：To investigate the peripheral blood level of carcinoembryonic antigen-related cell adhesion molecular1（CEACAMl） in patients with thyroid cancer and its diagnostic value for thyroid cancer.Methods：Using ELISA assay,the serum CEACAMl levels in 76 thyroid cancer patients,48 patient with benign thyroid tumor and 38 healthy subjects were determined,and meanwhile,the levels of carcinoembryonic antigen（CEA） and thyroglobulin（TG） were also measured.The relations of CEACAMl level with clinicopathologic characteristics of thyroid cancer were analyzed.Through drawing ROC curves,the diagnostic values for thyroid cancer among CEACAMl,CEA and TG were compared.Results：The serum CEACAMl level in thyroid cancer patients was significantly higher than that in patients with benign thyroid tumor or healthy control individuals（547.11 ng/mL vs.469.77 ng/mL and 369.04 ng/mL,both P〈0.05）.The serum CEACAMl level was significantly associated with TNM stage and lymph node metastasis of thyroid cancer patients（both P〈0.05）.The area under the ROC curve of CEACAMl for diagnosis of thyroid cancer was 0.94,with sensitivity of 97.4%and specificity of 80.3%,and the diagnostic value of CEACAMl for thyroid cancer was superior to that of CEA or TG.Conclusion：Serum CEACAM1 detection has certain value for diagnosis and disease assessment of thyroid cancer.