同时性双侧乳腺癌与异时性双侧乳腺癌预后差异的Meta分析

Prognostic difference of synchronous versus asynchronous bilateral breast cancer: a Meta-analysis

目的：系统评价同时性双侧乳腺癌（SBBC）与异时性双侧乳腺癌（ABBC）预后差异。方法：计算机检索国内外数据库,收集相关文献,经文献筛选、质量评价和资料提取后,对符合纳入标准的研究采用Revman 5.3软件进行Meta分析。结果：共纳入7个研究,共711例患者,其中SBBC患者225例,ABBC患者486例。Meta分析结果显示,SBBC患者组1、5、10年生存率均明显低于ABBC患者（OR=0.41,95%CI=0.22-0.77,P=0.005;OR=0.52,95%CI=0.39~0.69,P〈0.00001;OR=0.43,95%CI=0.25-0.74,P=0.003）。结论：在同等医疗条件下,SBBC的预后可能差于ABBC,但仍需作进一步的完整评估。

Objective：To systematically assess the prognostic difference between synchronous bilateral breast cancer（SBBC）and asynchronous bilateral breast cancer（ABBC）.Methods：The relevant studies were collected by searching the national and international online databases.After literature screening,quality assessment and data extraction,Meta-analysis was performed by using RevMan 5.3software.Results：Seven studies were finally included,involving 711 patients,with 225 SBBC cases and 486 ABBC cases.The results of Meta-analysis showed that the 1-,5- and 10-year survival rates in SBBC patients were significantly lower than those in ABBC patients（OR=0.41,95%CI=0.22-0.77,P=0.005;OR=0.52,95%CI=0.39-0.69,P〈0.00001;OR=0.43,95%CI=0.25-0.74,P=0.003）.Conclusion：The prognosis of SBBC is probably poorer than that of ABBC under the same medical circumstances and,however,further complete evaluation remains to be done.