活化细胞黏附分子在甲状腺癌中的表达及其临床意义

Expression and clinical significance of activated-leukocyte adhesion molecule in thyroid carcinoma

目的:研究活化细胞黏附分子(ALCAM)在甲状腺癌组织中表达及其临床意义。方法:免疫组织化学法检测52例甲状腺癌组织及对应癌旁正常甲状腺组织中ALCAM的表达,比较ALCAM在两种组织中表达的差异,并分析其表达与甲状腺癌患者临床病理因素及预后的关系。结果:ALCAM在甲状腺癌组织中的阳性表达率明显高于癌旁正常甲状腺组织(71.2%vs.34.6%,P<0.05),但在ALCAM在甲状腺癌组织中表达越低,甲状腺癌组织病理分化程度越低,患者5年总生存率越低(均P<0.01)。结论:ALCAM表达增高可能参与甲状腺癌发生发展进程,然而,在恶性度高、预后差的甲状腺癌的肿瘤组织中ALCAM表达反而降低的原因推测可能与其脱落释放入血有关。

Objective：To investigate the expression of activated-leukocyte adhesion molecule（ALCAM） in thyroid cancer tissue and the clinical significance.Methods：ALCAM expressions in 52 samples of paired thyroid cancer and adjacent normal thyroid tissues were detected by immuohistochemical staining.The ALCAM expression difference between the two types of tissues was compared,and relations of ALCAM expression with clinicopathologic features and prognosis of the thyroid cancer patients were analyzed.Results：The positive ALCAM expression rate in thyroid cancer tissue was significantly higher than that in adjacent normal thyroid tissue（71.2%vs.34.6%,P〈0.05）,but in thyroid cancer tissue,the lower ALCAM expression was associated with poorer histopathological differentiation of the thyroid cancer,and shorter 5-year overall survival of the patients（both P〈0.01）.Conclusion：Increased ALCAM expression may be involved with the occurrence and development of thyroid cancer.However,the phenomenon of ALCAM expression contrarily reduced in tumor tissues from highly malignant and poor prognostic thyroid cancer is speculated to be related to its detachment and release into the circulation.