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骨髓涂片和流式细胞术诊断非霍奇金淋巴瘤骨髓侵犯的临床价值比较 被引量:7

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摘要 目的比较骨髓细胞形态学(BMA)和流式细胞术(FCM)诊断非霍奇金淋巴瘤(NHL)患者骨髓侵犯的临床价值。方法回顾性分析本院在2013-2014年间收治的207例NHL患者的骨髓涂片及流式细胞免疫表型的检测结果,分析2种检测方法在不同程度、不同形态淋巴瘤骨髓侵犯的临床价值。结果经2种方法联合检测,总体阳性率为24.6%(51/207)。BMA和FCM的骨髓侵犯阳性率分别为17.4%(36/207)和22.2%(46/207);其中阳性结果一致者29例,主要表现于高比例瘤细胞骨髓侵犯的病例;不一致36例多见于低比例瘤细胞骨髓侵犯的病例(17.4%),16例FCM检测为阳性而BMA为阴性的病例主要为轻度异形小细胞淋巴瘤,8例BMA阳性而FCM为阴性的病例为高度异形大细胞淋巴瘤。结论 BMA、FCM在诊断不同形态淋巴瘤细胞侵犯的敏感性不同,FCM诊断轻度异形细胞淋巴瘤骨髓侵犯的敏感性高于BMA,BMA检测高度异型大细胞淋巴瘤骨髓侵犯优于FCM,两者联合检测可提高骨髓侵犯的阳性率。
作者 刘敏 井昶雯
出处 《临床检验杂志》 CAS CSCD 2015年第9期659-661,共3页 Chinese Journal of Clinical Laboratory Science
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参考文献8

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