以奥美拉唑为主的三联疗法治疗小儿消化性溃疡

Omeprazole-based Triple Therapy for Treatment of Children with Peptic Ulcer

目的讨论研究应用以奥美拉唑为主的三联疗法治疗小儿消化性溃疡的临床疗效与意义。方法随机选取该院儿科消化性溃疡患者60例。随机分为A、B两组。A组患者使用奥美拉唑、克拉霉素片及阿莫西林进行治疗;B组患者使用西咪替丁、克拉霉素片、阿莫西林治疗。比较两组患者治疗后总有效率以及幽门螺杆菌根除率等指标。结果 A组以奥美拉唑为主使用三联疗法治疗后其幽门螺杆菌清除率86.7%显著优于其他药物组73.3%(P<0.05);A组以奥美拉唑为主三联疗法治疗后总有效率100%显著优于常规治疗B组93.3%(P<0.01)。结论应用以奥美拉唑为主的三联疗法治疗小儿消化性溃疡可有效提高幽门螺杆菌根除率。可缩短疾,病治疗时间并促进恢复,更能够显著降低疾病复发率,快速改善胃黏膜糜烂并抑制细菌闭合成。

Objective To discuss the clinical effect and significance of omeprazole-based triple therapy in children with peptic ulcer.Methods 60 children with peptic ulcer in our hospital,were randomly divided into A,B two groups.Patients in the group A was given triple therapy of omeprazole,clarithromycin tablets and amoxicillin;while those in the group B received treatment of cimetidine,clarithromycin tablets and amoxicillin.Indexes including the total efficiency and Helicobacter pylori eradication rate of the two group was compared.Results Clearance rate of 86%is significantly better than other drugs group 72%the Helicobacter pylori A group with omeprazole based triple therapy using after treatment（P〈0.05）;A group with omeprazole-based triple therapy after treatment,the total efficiency of 100%was significantly higher than that of conventional treatment and 96%in B group（P〈0.05）.Conclusion The application of omeprazole-based triple therapy for treatment of children with peptic ulcer can effectively improve the eradication of helicobacter pylori and shorten the treatment time,promote recovery,significantly reduce the relapse rate of the disease,inhibits gastric acid secretion and rapidly improve the erosion of gastric mucosa.