关于多中心骨巨细胞瘤的系统回顾

Systematic review of multicentric giant cell tumor of bone

骨巨细胞瘤是一种具有侵袭性的良性骨肿瘤,常为单发病灶,多中心发病者罕见,报道以个案为主。为进一步分析多中心骨巨细胞瘤的基本特点,总结其治疗方法和预后情况,作者搜集了国内外数据库中关于多中心骨巨细胞瘤的病例研究,对其做出了系统的分析和归纳,旨在为临床医生提供更多参考。多中心骨巨细胞瘤的发病年龄相对年轻,好发于骨骼未成熟的患者,女性多于男性,干骺端及手足骨的发病率高于单发者。病理组织学检查是明确诊断的最终手段,对患者进行系统的影像和核医学检查可以避免漏诊,在治疗时要求坚持对各个病灶独立评估其特点,确定治疗方案。多中心骨巨细胞瘤患者及高危患者应坚持长期随访。

Giant cell tumor of bone is a common benign and aggressive neoplasm. In most cases, patients present solitary lesions while only a few are muhifocal. In order to further analysize its clinical, pathological and radiographic features as well as its prognosis, we systematically collected cases and series reports of muhifocal giant cell tumor of bone worldwide from six elec- tronic databases and made this systematic review. The results reveal that muhifocal giant cell tumor is more likely to involve young, female and skeletally - immature individuals compared with solitary giant cell tumor. We also noted a higher incidence of the hand and feet disease and metaphyses of long bones in muhicentric patients group. Pathologically examination is the decisive technique to diagnose this disease and systematically biographic or nuclear medical examination is indispensable to avoid missed diagnosis. Each lesion should be assessed independently when making treatment plan and long - term follow - up should be insis- ted for patient with or susceptible to muhifocal giant cell tumor.