乳腺癌新辅助化疗动脉灌注途径与静脉途径的对比

Comparative analysis of artery infusion chemotherapy and intravenous chemotherapy of neoadjuvant chemotherapy for breast cancer

目的探讨乳腺癌新辅助化疗动脉灌注途径和静脉途径化疗的有效性。方法收集92例乳腺癌患者,均采用多柔比星为主的联合化疗方案,其中动脉组44例,行肿瘤区域动脉灌注化疗,必要时栓塞肿瘤供血动脉;静脉组48例,使用外周静脉全身化疗。观察两组患者的近期临床疗效及长期生存率。结果动脉组近期临床疗效明显优于静脉组(P<0.05),但长期生存期率两组间差异无统计学意义(P>0.05)。结论动脉灌注化疗可作为乳腺癌新辅助化疗的有效途径之一。

Objective To explore the efficacy of neoadjuvant chemotherapy for breast cancer by comparing the effects of artery infusion chemotherapy and intravenous chemotherapy. Methods A total of 92 patients with breast cancer were en- rolled, including 44 patients in artery infusion chemotherapy group and 48 patients in intravenous chemotherapy group, which all induced doxorubicin in combined chemotherapy. Chemotherapeutics were induced in tumor region by arterial infu- sion, and feeding arteries of tumor were embolized if necessary in artery infusion chemotherapy group. Intravenous chemo- therapy was done in intravenous chemotherapy group. The short-term curative effects and long-term survival rate of the two groups were compared. Results The short-term curative effect in artery infusion chemotherapy group was significantly better than that of intravenous chemotherapy group （P〈0.05）, but there was no statistical significance difference of the long-term survival between the two groups （P〉0.05）. Conclusion Arterial infusion chemotherapy could be one of the ef- fective methods of neoadjuvant chemotherapy for breast cancer.