甲状腺全切术治疗甲状腺癌的安全性分析

Analysis of Safety of Total Thyroidectomy in the Treatment of Thyroid Carcinoma

目的探讨甲状腺全切术治疗甲状腺癌的安全性。方法将593例甲状腺癌患者分为观察组(102例)与对照组(491例)。观察组采用甲状腺全切术进行治疗,对照组采用甲状腺次全切术或甲状腺近全切术治疗。治疗结束后,所有患者均接受24个月的随访。结果 2组患者暂时性单侧喉返神经损伤、永久性单侧喉返神经损伤发生率相比,差异无统计学意义(P>0.05)。观察组暂时性甲状旁腺功能低下、永久性甲状旁腺功能低下发生率显著高于对照组,差异有统计学意义(P<0.05)。结论甲状腺全切术治疗甲状腺癌的主要不足之处是患者术后易发生甲状腺功能低下,这在选择甲状腺全切术时应给予重视。

Objective To investigate the safety of total thyroidectomy in the treatment of thyroid carcinoma.Methods 593 cases of thyroid carcinoma were divided into the observation group（102 cases） and the control group（491 cases） according to their surgical methods,and the observation group received total thyroidectomy,while the control group was given thyroid sub-to-tal resection or thyroid near-total resection.All patients were followed up for 24 months after treatment.Results There were no significant differences in the incidence of transient unilateral recurrent laryngeal nerve injury and permanent unilateral recurrent laryngeal nerve injury between the 2 groups（P〉0.05）.The incidence of transient parathyroid dysfunction and permanent para-thyroid dysfunction in the observation group were significantly higher than those of the control group respectively（ P〈0.05）. Conclusion The main shortcoming of total thyroidectomy in the treatment of thyroid carcinoma is that it is easy to occur transient parathyroid dysfunction after surgery,which should be taken into consideration when total thyroidectomy is performed.