多奈哌齐治疗阿尔茨海默病的效果评价与临床意义

Effects evaluation and clinical significance of donepezil treatment for Alzheimer's disease

目的探讨使用多奈哌齐治疗阿尔茨海默病(AD)患者的治疗效果和临床意义。方法选取86例确诊为阿尔茨海默病老年患者,按照随机数字表法,选取接受多奈哌齐治疗的45例患者为观察组,其他41例患者纳入为对照组。结果观察组接受多奈哌齐治疗的总有效率(91.11%)显著高于对照组(61.52%),差异有统计学意义(χ2=11.21,P=0.004);观察对象接受治疗12月后的简明智力状态检查(MMSE)、阿尔茨海默病评定量表认知分量表(ADAS-cog)、日常生活能力量表(ADL)评分显著低于对照组,差异有统计学意义(P<0.05);观察组受试对象血清中的白细胞介素6(IL-6)(t=7.485,P<0.01)、白细胞介素10(IL-10)(t=5.584,P<0.01)、肿瘤坏死因子-α(TNF-α)(t=2.415,P=0.018)显著低于对照组水平,差异有统计学意义(P<0.05);观察组受试对象治疗1年后的血清炎症标志物IL-6、IL-10、TNF-α与MMSE、ADL评分情况呈负相关,与ADAS-cog评分呈正相关。结论多奈哌齐对治疗阿尔茨海默病的患者效果较好。

Objective To explore effects and clinical significance of donepezil treatment for Alzheimer＇s disease. Methods Eighty-six cases of Alzheimer＇s disease were selected from our hospital and were randomly divided into the observation group （n = 45） who received donepezil, and other patients as the control group （n = 41 ）. Results The total effective rate of treatment in observation group was significantly higher than that in the control group（x^2 = 11.21 ,P = 0.004）. After 12 months treatment, the MMSE, ADAS-cog, ADL scores of observation group were signifi- candy lower than those in the control group （P 〈 0.05 ） ; and the serum IL-6 （ t = 7.485, P 〈 0.01 ）, IL-10 （ t = 5.584, P 〈 0.01 ）, the TNF alpha（ t = 2.415, P = 2. 415 ） of observation group were significantly lower than those in control group（P 〈0.05）. The serum inflammatory markers IL-6,IL-10,and TNF alpha of observation group,which were neg- atively correlated with MMSE,ADL scores were positively correlated with ADAS-cog scores. Conclusion Donepezil treatment for Alzheimer＇ s disease has a better effect.