门冬氨酸鸟氨酸联合纳洛酮治疗急性肝性脑病的疗效观察

The clinical effect of ornithine aspartate combined with naloxone in the treatment of acute hepatic encephalopathy

目的观察门冬氨酸鸟氨酸联合纳洛酮治疗急性肝性脑病的临床疗效。方法 60例急性肝性脑病患者采取随机数字表法分为门冬氨酸鸟氨酸组15例,纳洛酮组15例及联合治疗组30例,比较3组治疗前后血氨及转氨酶指标,评价临床疗效。结果门冬氨酸鸟氨酸组和纳洛酮组与联合治疗组相比,血氨及转氨酶水平差异均有统计学意义(P<0.05),联合治疗组总有效率明显高于门冬氨酸鸟氨酸组和纳洛酮组,差异有统计学意义(P<0.05)。结论门冬氨酸鸟氨酸和纳洛酮联合治疗急性肝性脑病患者可显著提高临床疗效,改善预后,值得临床推广。

Objective To observe the clinical effect of ornithine aspartate combined with naloxone in the treatment of acute hepatic encephalopathy.Methods 60 cases with acute hepatic encephalopathy were selected and randomly divided into the con‐trol group A （n=15） receiving ornithine aspartate ,the control group B （n=15） receiving naloxone ,the experimental group （n=30） receiving the treatment of ornithine aspartate combined naloxone. To assess the clinical curative effect ,we evaluated and compared the plasma ammonium levels and transaminase indicators before and after treatment.Results Compared with experi‐mental group ,the plasma ammonium levels and transaminase indicators in the control group A and control group B showed sta‐tistical differences （P〈0.05）;In addition ,the total effective rate of experimental group was significantly higher than that of the control group A and control group B （P〈0.05）.Conclusion The treatment of ornithine aspartate combined with naloxone in acute hepatic encephalopathy patients can effectively ameliorate the clinical symptoms and improve the clinical curative effect , which should be worthy of clinical application.