丹栀逍遥散联合艾司西酞普兰片治疗缺血性脑卒中后抑郁症对患者总体康复的影响

The effect of Danzhi Xiaoyao power combined with escitalopram on the general recovery in patients with depression after ischemic stroke

目的探讨丹栀逍遥散联合艾司西酞普兰片治疗缺血性脑卒中后抑郁症对患者总体康复水平的影响。方法将68例缺血性脑卒中后抑郁症患者按入院顺序随机分为观察组和对照组。对照组予以艾司西酞普兰片口服,初始剂量5mg/d,连服3d,3d后改为10mg/d口服;观察组在此基础上加用丹栀逍遥散加减治疗,水煎服,3次/d,100mL/次,2组疗程均为8周。观察2组患者的HAMD评分、Hcy水平、血脂水平及不良反应。结果治疗后4周及治疗后6周,2组HAMD评分比较差异有统计学意义(P<0.05),观察组较对照组HAMA评分减少显著;观察组治疗后Hcy水平较治疗前显著下降,差异有统计学意义(P<0.05),对照组治疗后Hcy无显著变化。对照组治疗后血脂水平较治疗前无明显变化,观察组治疗后TC、TG较治疗前下降(P<0.05);观察组治疗后H-DLC较治疗前增高(P<0.05)。2组不良反应差异无统计学意义。结论丹栀逍遥散联合艾司西酞普兰片治疗缺血性脑卒中后抑郁症对患者总体康复水平有积极的影响。

Objective To study the effect of Danzhi Xiaoyao power combined with escitalopram on the overall rehabilitation in patients with depression after ischemic stroke.Methods 68 cases with depression after ischemic stroke were randomly divid‐ed into observation group and control group according to the admission order.Patients in control group received escitalopram tablets orally with the initial dose of 5mg/d for 3 days and then 10mg/d instead.Based on the control group ,patients in obser‐vation group received modified therapy of Danzhi Xiaoyao power orally with the volume of 100mL three times daily for 8 weeks treatment. We observed the HAMD scores ,Hcy levels ,lipid levels and adverse reactions of the two groups.Results After 4‐week and 6‐week treatment ,the HAMD scores in two groups showed statistical difference （P〈0.05） ,which were remarkably lower in observation group than that in control group. Compared with pre‐treatment ,Hcy levels decreased significantly after treatment in observation group with a statistical difference （P〈0.05） ,which had no significant difference in control group. In terms of liquid levels ,there was no significant change in the control group after treatment ,while the TC and TG levels de‐creased significantly and H‐DLC level increased significantly in the observation group after treatment （P〈0.05）. In addition , there was no significant difference between the two groups as for adverse reactions.Conclusion The therapy of Danzhi Xiaoyao power combined with escitalopram has positive effect on the general recovery in patients with depression after ischemic stroke.