急性脑卒中患者血清瘦素的检测及对神经功能康复的影响

Detection of serum leptin and its effect on neurological rehabilitation in acute stroke patients

目的探讨急性脑卒中患者血清瘦素的水平变化及对神经功能康复的影响。方法随机选取急性脑卒中患者80例为实验组,60例正常体检者为对照组,所有患者均于入院次日空腹采用放射免疫法检测其血清瘦素水平并测体重指数。据急性脑卒中患者的体重指数将患者分为过轻、正常、适中、过重、肥胖、非常肥胖6个亚组,治疗30d后用美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)检测6个亚组的神经功能情况。结果实验组血清瘦素水平较对照组明显升高(P<0.01),且患者血清瘦素的水平越高,治疗30d的NIHSS评分越高(r=0.937、0.650、0.638、0.837、0.914、0.889,t=6.013、3.825、3.796、4.593、5.521、5.146,P<0.001)。结论急性脑卒中患者血清瘦素水平较正常人明显升高,且血清瘦素水平越高,神经功能康复情况越差;可在一定程度上预测患者的神经功能康复水平,并指导临床治疗,进一步提高康复程度。

Objective To investigate serum leptin levels in acute stroke patients and its impact on neurological rehabilita‐tion. Methods We randomly selected 80 patients with acute stroke as the experimental group and 60 healthy individuals as the control group. The fasting serum leptin was determined by radioimmunoassay and the body mass index was measured in all par‐ticipants the next day after admission. All patients with acute stroke were divided into six levels of underweight ,normal ,mod‐erate ,overweight ,obese and hyper‐obese subgroup according to body mass index. Then we detected neurological conditions of six subgroups based on NIHSS after 30‐day treatment. Results The serum leptin levels in the experimental group were signifi‐cantly higher than that in the control group （P〈0.01） ,and the higher the patients had the levels of serum leptin ,the higher NIHSS scores were after 30‐day treatment （r=0.937 ,0.650 ,0.638 ,0.837 ,0.914 ,0.889 ;t=6.013 ,3.825 ,3.796 ,4.593 , 5.521 ,5.146 ,P〈0.001）.Conclusion Serum leptin levels in patients with acute stroke are significantly higher than that in controls ,and the higher the serum leptin levels ,the worse the situation neurological rehabilitation ,which can predict the level of the patient＇s neurological rehabilitation to some extent ,and can guide clinical treatment to improve the degree of recovery.