两种内膜准备方案冻融胚胎移植妊娠结局的回顾性分析

Pregnancy Outcomes of Two Methods of Endometrium Preparation for Froze-Thawed Embryos Transfer: Retrospective Study

目的:探讨自然周期(NC)与激素替代治疗(HRT)方案准备内膜对冻融胚胎移植(FET)妊娠结局的影响。方法:回顾性分析我院生殖中心行FET的111个周期。根据子宫内膜准备方案分为NC组(69周期)和HRT组(42周期),比较分析2组的年龄、不孕时间、解冻胚胎数、移植胚胎数、移植优胚数、转化日内膜厚度、胚胎种植率、临床妊娠率及早期流产率。结果:2组年龄、不孕时间、解冻胚胎数、移植胚胎数、移植优胚数、转化日内膜厚度、临床妊娠率、胚胎种植率和早期流产率差异均无统计学意义(P>0.05)。结论:NC方案及HRT方案可获得相似的妊娠结局,临床工作中可根据患者情况选择个体化子宫内膜准备方案,做到方便患者、简单易行、费用低、不良反应少,妊娠结局好。

Objective ：To investigate the effects of two methods of endometrium preparation for froze- thawed embryos transfer （FET）, using natural cycle and hormone replacement therapy. Methods： III cycles of FET were retrospectively analyzed. Those cycles were divided into two groups：the natural cycle group （69 cases）, and the hormone replacement group （42 cases）. The clinical parameters were compared between the two groups, including age, infertility duration, the number of thawed embryo, the number of transplanted embryo, the number of high-quality post-implantation embryo, endometrial thickness on the day of endometrial transformation, embryo implantation rate, clinical pregnancy rates and early abortion rate. Results：There were no significant differences between the two groups in age, infertility duration, the number of thawed embryo, the number of transplanted embryo, the number of high-quality post-implantation embryo, endometrial thickness on the day of endometrial transformation, clinical pregnancy rate, embryo implantation rate and early abortion rate （P〉0.05）. Conclusions：There are same pregnancy outcomes using the two ways of endometrium preparation for FET. The way to prepare endometrium for those FET patients should be taken individually.