自拟汤剂结合五氟利多片治疗反应性精神病的疗效观察

Analysis of penfluridol combined with self-made decoction in the treatment of reactive psychosis

目的观察自拟汤剂结合五氟利多片治疗反应性精神病的疗效及安全性。方法选取94例反应性精神病患者作为研究对象,随机分为观察组和对照组,各47例:对照组单用五氟利多片治疗;观察组以自拟汤剂联合五氟利多片治疗。对比两组疗效、治疗前后住院患者护士观察评定量表(NOSIE-30)评分、药物不良反应发生情况。结果观察组总有效率(95.7%)明显优于对照组(83.0%),治疗后NOSIE-30总积极因素评分明显更高而总消极因素评分明显更低,差异有统计学意义(P<0.05)。两组药物不良反应无明显差异。结论自拟汤剂有助于提升五氟利多片对反应性精神病的治疗效果,且不会增加药物不良反应。

Objective To investigate the efficacy and safety of self-made decoction combined with penfluridol in the treatment of reactive psychosis. Methods 94 patients with reactive psychosis were randomly divided into two groups. The control group were treated by penfluridol while the observationgroup were treated with self-made decoction combined with penfluridol. Their curative effect, NOSIE-30 scores, and incidence of adverse drug reactions were compared. Results The effective rate of the observation group was significantly better （P 〈 0.05 ）. After treatment, the score of total positive factors in NOSIE-30 scale of the observation group was significantly higher while the total negative factors score was significantly lower （P 〈 0.05 ）. Two groups have no obvious differences in adverse drug reaction. Conclusion The self-made decoction is helpful to improve treatment effects of penfluridol to reactive psychosis. And it won＇ t increase adverse drug reactions.